Searchable abstracts of presentations at key conferences in endocrinology

ea0063ep64 | Diabetes, Obesity and Metabolism | ECE2019

Intensive treatment for obesity at our hospital

Matsuura Bunzo , Senba Hidenori , Yamamoto Shin , Miyake Teruki , Furukawa Shinya , Hiasa Yoichi , Watanabe Yuji

Since 2006 at our hospital, lifestyle modification, such as diet and exercise, for obese patients has been provided through a team approach with a physician, dietician, physical therapist and psychologist. From 2016, a surgeon, anesthesiologist and nurse were added to the team for metabolic/bariatric surgery. The aims of this study are to clarify the effectiveness and problems of lifestyle modification, and to clarify the characteristics of patients who transferred for surgica...

ea0056p743 | Neuroendocrinology | ECE2018

Desensitization of the human motilin receptor by motilin and motilides

Matsuura Bunzo , Takano Akiko , Kawamura Tomoe , Yamamoto Shin , Senba Hidenori , Miyake Teruki , Furukawa Shinya , Abe Masanori , Hiasa Yoichi

The motilin receptor (MLNR) belongs to a family of Class I G protein-coupled receptors, and is an important endogenous regulator of gastrointestinal motor function. Motilin and erythromycin (EM), two chemically distinct full agonists of the motilin receptor, bind to distinct regions of this receptor, while the action of these different chemical classes of agonists likely yields a common activation state of the cytosolic face of this receptor that is responsible for interaction...